Palladium-Catalyzed C–P(III) Bond Formation by Coupling ArBr/ArOTf with Acylphosphines
Nanjun Chen, Hongyu Wu, Rongrong Yu, Hong Zhu, Zhiqian Wang
Abstract
Palladium-catalyzed C-P bond formation reaction of ArBr/ArOTf using acylphosphines as differential phosphination reagents is reported. The acylphosphines show practicable reactivity with ArBr and ArOTf as the phosphination reagents, though they are inert to the air and moisture. The reaction affords trivalent phosphines directly in good yields with a broad substrate scope and functional group tolerance. This reaction discloses the acylphosphines' capability as new phosphorus sources for the direct synthesis of trivalent phosphines.
Topics & Concepts
ChemistryPalladiumCatalysisCoupling (piping)Medicinal chemistryOrganic chemistryMetallurgyMaterials scienceCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization Methods