Oxygen-Free Regioselective Biocatalytic Demethylation of Methyl-phenyl Ethers via Methyltransfer Employing Veratrol-<i>O</i>-demethylase
Christopher Grimm, Mattia Lazzarotto, Simona Pompei, Johanna Schichler, Nina Richter, Judith E. Farnberger, Michael Fuchs, Wolfgang Kroutil
Abstract
-yatein. The approach presented here represents an alternative to chemical and enzymatic demethylation concepts and allows performing regioselective demethylation in the absence of oxygen under mild conditions, representing a valuable extension of the synthetic repertoire to modify pharmaceuticals and diversify natural products.
Topics & Concepts
RegioselectivityChemistryDemethylationArylOrganic chemistryCombinatorial chemistryCatalysisBiochemistryAlkylGene expressionGeneDNA methylationPorphyrin Metabolism and DisordersPolyamine Metabolism and ApplicationsEnzyme Catalysis and Immobilization