Polymeric Nanotubes as Drug Delivery Vectors─Comparison of Covalently and Supramolecularly Assembled Constructs
Andrew T. Kerr, Erny Sagita, Edward D. H. Mansfield, Tri‐Hung Nguyen, Orlagh M. Feeney, Colin W. Pouton, Christopher J. H. Porter, Joaquı́n Sanchis, Sébastien Perrier
Abstract
> 35 h), with the cyclic peptide system displaying an intermediate half-life (14.6 h), although still substantially elevated over a non-assembling linear control (2.7 h). The covalently bound BB underwent substantial distribution into the liver, whereas the cyclic peptide nanotube was able to mostly circumvent organ accumulation, highlighting the advantage of the inherent degradability of the cyclic peptide systems through their reversible aggregation of hydrogen bonding core units.
Topics & Concepts
Covalent bondPeptideCyclic peptideChemistryDrug deliveryIn vivoBiophysicsNanoparticleIn vitroCombinatorial chemistryNanotechnologyStereochemistryBiochemistryMaterials scienceOrganic chemistryBiologyBiotechnologySupramolecular Self-Assembly in MaterialsRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques