An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Marco Demaria, Naoko Ohtani, Sameh A. Youssef, Françis Rodier, Wendy Toussaint, James R. Mitchell, Rémi-Martin Laberge, Jan Vijg, Harry van Steeg, Martijn E.T. Dollé, Jan H.J. Hoeijmakers, Alain de Bruin, Eiji Hara, Judith Campisi
Topics & Concepts
BiologyWound healingPlatelet-derived growth factor receptorSenescencePhenotypeSecretionMyofibroblastPlatelet-derived growth factorCell biologyGrowth factorCancer researchImmunologyReceptorPathologyEndocrinologyGeneticsFibrosisGeneMedicineTelomeres, Telomerase, and SenescenceWound Healing and TreatmentsNeutrophil, Myeloperoxidase and Oxidative Mechanisms