Spatial analysis of nanoparticle distribution in human breast xenografts reveals nanoparticles targeted to cancer cells localized with tumor-associated stromal cells
S. B. Healy, Elizabeth Henderson, Suqi Ke, Jacqueline Kelly, Brian W. Simons, Chen Hu, Robert Ivkov, Preethi Korangath
Abstract
Antibody-labeled nanoparticles were retained across all tumors, irrespective of presence of the "target" antigen. Though presence of antibody on nanoparticles correlated with retention, non-cancerous host stromal cells were responsible for their retention in the tumor microenvironment. This study highlights gaps in our understanding of the complex biological interplay between disease and host immune biology, and the need to account for the influence of underlying aberrant tumor biology as factors determining nanoparticle fate in vivo.
Topics & Concepts
Stromal cellCancer researchTumor microenvironmentAntibodyCancerCancer cellChemistryImmune systemNanoparticleBreast cancerPathologyBiologyImmunologyMedicineNanotechnologyMaterials scienceInternal medicineNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsImmunotherapy and Immune Responses