ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer’s disease
Zhi-Hao Wang, Yiyuan Xia, Pai Liu, Xia Liu, Laura E. Edgington‐Mitchell, Kecheng Lei, Shan Ping Yu, Xiaochuan Wang, Keqiang Ye
Topics & Concepts
PathogenesisAmyloid precursor protein secretaseProinflammatory cytokinePresenilinAlzheimer's diseaseApolipoprotein ESignal transductionCell biologyBiologyEndocytosisNeurodegenerationAmyloid precursor proteinNeuroscienceInternal medicineMedicineInflammationImmunologyDiseaseBiochemistryReceptorAlzheimer's disease research and treatmentsCholesterol and Lipid MetabolismTryptophan and brain disorders