IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression
Maha Almanan, Jana Raynor, Ireti Ogunsulire, Anna Malyshkina, Shibabrata Mukherjee, Sarah A. Hummel, Jennifer T Ingram, Ankur Singh Saini, Markus M. Xie, Theresa Alenghat, Sing Sing Way, George S. Deepe, Senad Divanovic, Harinder Singh, Emily R. Miraldi, Allan Zajac, Alexander L. Dent, Christoph Hölscher, Claire Chougnet, David A. Hildeman
Abstract
regulatory and follicular regulatory cells did not. Thus, these data demonstrate that immune suppression with age is reversible and implicate Tfh10 cells as an intriguing link between "inflammaging" and impaired immune responses with age.
Topics & Concepts
FOXP3Immune systemImmunologyInflammationAntibodyBiologyCytokinePhenotypeGeneticsGeneT-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses