The new synthesis of pyrrole-fused dibenzo[<i>b</i>,<i>f</i>][1,4]oxazepine/thiazepines by the pseudo-Joullié–Ugi reaction<i>via</i>an unexpected route with high chemoselectivity
Mohammad Taghi Nazeri, Masoomeh Ahmadi, Maryam Ghasemi, Ahmad Shaabani, Behrouz Notash
Abstract
with isocyanides and a variety of pyrrole-fused dibenzoxazepines/thiazepines are synthesized in a simple one-pot operation with high yields and chemoselectivity. This strategy opens a new route in Ugi reactions (pseudo-Joullié-Ugi reaction) for the synthesis of pyrrole-fused heterocycles as special pharmaceutical scaffolds.
Topics & Concepts
ChemoselectivityPyrroleChemistryCombinatorial chemistryZwitterionIsocyanideCatalysisOrganic chemistryMoleculeMulticomponent Synthesis of HeterocyclesSynthesis and Characterization of PyrrolesSynthesis and biological activity