Novel Strategies in the War Against Antibiotic Resistance
Stella Cascioferro, Barbara Parrino, Daniela Carbone, Camilla Pecoraro, Patrizia Diana
Abstract
The global threat of antibiotic resistance is steadily growing. Antibiotic resistancemay involve any class of antibiotic, including second- and third-line agents that have been considered to date the last-resort drugs to counteract common infections. We may lose our capability to keep under control many common bacterial infections [1]. Despite this, in the past decade significant research efforts have been made to develop new antibacterial strategies able to treat multidrug-resistant infections; however, no new therapeutic approach has yet reached the clinic [2,3]. In order to identify new valuable antimicrobial drugs, it is important to consider the main bacterial resistance mechanisms in both planktonic and sessile forms of life [4].