Engineering polymeric micelles for targeted drug delivery: “click” chemistry enabled bioconjugation strategies and emerging applications
Enfal Civril, Rana Sanyal, Amitav Sanyal
Abstract
click" transformation-based targeting strategies either through metabolic glycoengineering or stimuli-induced aggregation. This review focuses on the advances in the fabrication of ligand-based targeted micelles using the "click" reaction for ligand conjugation onto polymeric micelles and highlights recent applications of these materials for targeted drug delivery.
Topics & Concepts
BioconjugationBioorthogonal chemistryMicelleNanotechnologyChemistryDrug deliveryTargeted drug deliveryCombinatorial chemistryChemical biologySurface modificationClick chemistryPolymerSmart polymerDrugNanomedicineDrug discoveryMolecular engineeringSurface engineeringSynthetic biologyDrug carrierBiocompatible materialChemical modificationBiomimetic materialsClick Chemistry and ApplicationsAdvanced Polymer Synthesis and CharacterizationNanoparticle-Based Drug Delivery