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TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

Manling Xie, Yong Liu, Shunyi Zhao, Lingxin Zhang, Dale B. Bosco, Yuan‐Ping Pang, Jun Zhong, Udit Sheth, Yuka A. Martens, Na Zhao, Chia‐Chen Liu, Yongxian Zhuang, Liewei Wang, Dennis W. Dickson, Mark P. Mattson, Guojun Bu, Long‐Jun Wu

2021Nature Neuroscience167 citationsDOIOpen Access PDF

Topics & Concepts

TREM2NeurodegenerationMicrogliaNeuroprotectionNeuroscienceBiologyCell biologyImmunologyMedicineInflammationPathologyDiseaseNeuroinflammation and Neurodegeneration MechanismsInflammation biomarkers and pathwaysSpinal Cord Injury Research
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration | Litcius