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Berberine targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia with IDH1 mutation

Zhe Huang, Yunfu Shen, Wenjun Liu, Yang Yan, Ling Guo, Qin Yan, Chengming Wei, Qulian Guo, Xianming Fan, Wenzhe Ma

2023Chinese Journal of Natural Medicines13 citationsDOI

Topics & Concepts

Isocitrate dehydrogenaseIDH1ReprogrammingMyeloid leukemiaCancer researchBiologyOxidative phosphorylationIDH2EpigeneticsMutationGeneticsCellGeneBiochemistryEnzymeCancer therapeutics and mechanismsDrug Transport and Resistance MechanismsEpigenetics and DNA Methylation
Berberine targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia with IDH1 mutation | Litcius