Rifampin, Rifapentine, and Rifabutin Are Active against Intracellular Periprosthetic Joint Infection-Associated Staphylococcus epidermidis
Cody R. Fisher, Robin Patel
Abstract
Staphylococcus epidermidis is a major cause of periprosthetic joint infection (PJI); its intracellular persistence within osteoblasts may compromise therapy if that therapy is not intracellularly active. The intracellular activity of rifampin, rifapentine, and rifabutin was assessed against five rifampin-susceptible and two rifampin-resistant S. epidermidis isolates.
Topics & Concepts
RifabutinRifapentineStaphylococcus epidermidisMicrobiologyPeriprostheticMedicineIntracellularRifamycinAntibacterial agentAntibioticsBiologyStaphylococcus aureusBacteriaMycobacterium tuberculosisTuberculosisArthroplastySurgeryClarithromycinLatent tuberculosisPathologyGeneticsCell biologyOrthopedic Infections and TreatmentsAntimicrobial Resistance in StaphylococcusInfectious Diseases and Tuberculosis