Could an Unrelated Live Attenuated Vaccine Serve as a Preventive Measure To Dampen Septic Inflammation Associated with COVID-19 Infection?
Paul L. Fidel, Mairi C. Noverr
Abstract
We propose the concept that administration of an unrelated live attenuated vaccine, such as MMR (measles, mumps, rubella), could serve as a preventive measure against the worst sequelae of coronavirus disease 2019 (COVID-19). There is mounting evidence that live attenuated vaccines provide nonspecific protection against lethal infections unrelated to the target pathogen of the vaccine by inducing “trained” nonspecific innate immune cells for improved host responses against subsequent infections.
Topics & Concepts
ImmunologyMeaslesAttenuated vaccineRubellaImmune systemMedicineVirologyInflammationInnate immune systemPathogenBiologyVaccinationBiochemistryVirulenceGeneImmune responses and vaccinationsCOVID-19 epidemiological studiesSARS-CoV-2 and COVID-19 Research