Vessel Wall MRI Enhancement in Noninflammatory Cerebral Amyloid Angiopathy
Qing Hao, Nadejda M. Tsankova, Hazem Shoirah, Christopher P. Kellner, Kambiz Nael
Abstract
Cerebral amyloid angiopathy is characterized by deposition of amyloid-β fibrils in the walls of small-to-medium-sized blood vessels. In this retrospective review of 5 patients with histologically confirmed noninflammatory cerebral amyloid angiopathy, high-resolution vessel wall MRI showed arterial wall enhancement in 2 patients (40%). Despite common consensus of equating vessel wall enhancement with inflammation, this report demonstrates that β-amyloid accumulation alone without inflammation can be associated with arterial wall enhancement in a subset of patients.
Topics & Concepts
Cerebral amyloid angiopathyMedicineAmyloid (mycology)Arterial wallPathologyAngiopathyInflammationAmyloidosisDementiaCardiologyInternal medicineDiseaseEndocrinologyDiabetes mellitusIntracerebral and Subarachnoid Hemorrhage ResearchAlzheimer's disease research and treatmentsAmyloidosis: Diagnosis, Treatment, Outcomes