An Overview: The Diversified Role of Mitochondria in Cancer Metabolism
Yue Liu, Yihong Sun, Yadong Guo, Xiaoyun Shi, Xi Chen, Wenfeng Feng, Leilei Wu, Jin Zhang, Shibo Yu, Yi Wang, Yufeng Shi
Abstract
/NADH to prevent metastasis and progression of cancers. In this review, we discussed mitochondrial function in cancer cell metabolism and specially explored the unique role of mitochondria in cancer stem cells and the tumor microenvironment. Targeting the OXPHOS pathway and mitochondria-related metabolism emerging as a potential therapeutic strategy for various cancers.
Topics & Concepts
MitochondrionOxidative phosphorylationBiologyCancer cellCell biologyCitric acid cycleGlycolysisBioenergeticsNAD+ kinaseBiochemistryCancerCellMetastasisMetabolismEnzymeGeneticsCancer, Hypoxia, and MetabolismMitochondrial Function and PathologyRNA modifications and cancer