Catalytic photochemical enantioselective α-alkylation with pyridinium salts
Santhivardhana Reddy Yetra, Nathan Schmitt, Uttam K. Tambar
Abstract
a light activated charge-transfer complex. We apply this photochemical stereoconvergent process to the total synthesis of the lignan natural products (-)-enterolactone and (-)-enterodiol. Mechanistic studies support the ground-state complexation of the reactive components followed by divergent charge-transfer processes involving catalyst-controlled radical chain and in-cage radical combination steps.
Topics & Concepts
Enantioselective synthesisPyridiniumAlkylationCatalysisChemistryOrganic chemistryPhotochemistryRadical Photochemical ReactionsAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization Methods