Design and biological evaluation of dual tubulin/HDAC inhibitors based on millepachine for treatment of prostate cancer
Shanshan Xie, Jiafu Leng, Shifang Zhao, Liqiao Zhu, Mengyu Zhang, Mengdan Ning, Bo Zhao, Lingyi Kong, Yong Yin
Topics & Concepts
ChemistryTubulinApoptosisIn vivoAcetylationCell cycle checkpointMicrotubuleProstate cancerCancer cellCell cycleIC50In vitroPharmacologyBiochemistryCancerCell biologyBiologyInternal medicineMedicineBiotechnologyGeneHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsUbiquitin and proteasome pathways