Cytokine Storm

Abstract

To the Editor: In their review article on cytokine storm, Fajgenbaum and June (Dec. 3 issue) 1 include a discussion of signaling by mitogenactivated protein kinase (MAPK), nuclear factor B, and mammalian target of rapamycin. We feel compelled to point out one major omission that has a clear therapeutic effect for cytokine storm in general and for therapies for coronavirus disease 2019 (Covid-19) in particular: the p38 MAPK-MAPKAPK2 pathway. 3] numbers, NCT04511819 and NCT04481685, respectively). These two drugs are expected to show efficacy that extends beyond that seen with single monotherapies directed at individual cytokines alone.

Topics & Concepts