Three-dimensional directional nerve guide conduits fabricated by dopamine-functionalized conductive carbon nanofibre-based nanocomposite ink printing
Shadi Houshyar, Mamatha M. Pillai, Tanushree Saha, G.B. Sathishkumar, Chaitali Dekiwadia, Satya Ranjan Sarker, R. Sivasubramanian, Robert A. Shanks, Amitava Bhattacharyya
Abstract
cell study of human glioma cells showed that the printed lines provided support for neural cell attachment, migration and differentiation toward the targeted end. In contrast, in the absence of printed lines in the scaffold, the cells attach and grow in random directions, forming a flower shape (cell cluster) on the surface of PCL. Thus, the proposed scaffold is a promising candidate for nerve guide application based on its signal transmission and navigating neurons in a correct pathway towards the targeted end.
Topics & Concepts
PolycaprolactoneMaterials scienceScaffoldNanocompositeNerve guidance conduitNanotechnologyRegeneration (biology)Biomedical engineeringNeural tissue engineeringPolymerComposite materialCell biologyBiologyMedicineGraphene and Nanomaterials ApplicationsNeuroscience and Neural EngineeringNerve injury and regeneration