Lung dendritic cells migrate to the spleen to prime long-lived TCF1 <sup>hi</sup> memory CD8 <sup>+</sup> T cell precursors after influenza infection
Meagan M. Jenkins, Holly Bachus, Davide Botta, Michael D. Schultz, Alexander F. Rosenberg, Beatriz León, André Ballesteros‐Tato
Abstract
T cells primed in the spleen are transcriptionally distinct and have enhanced ability to differentiate into long-lived memory cells compared with med-LN–primed counterparts. Thus, our data identify a lung mDC trafficking pathway that connects the lungs with the spleen.
Topics & Concepts
SpleenPriming (agriculture)LungBiologyImmunologyCD8Mediastinal lymph nodeLymph nodeLymphatic systemInfluenza A virusT cellAntigenVirusMedicineImmune systemInternal medicineGeneticsCancerMetastasisBotanyGerminationImmunotherapy and Immune ResponsesImmune Cell Function and InteractionT-cell and B-cell Immunology