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Annexin A1 Attenuates Neutrophil Migration and IL-6 Expression through Fpr2 in a Mouse Model of Streptococcus suis-Induced Meningitis

Chengpei Ni, Song Gao, Yuling Zheng, Peng Liu, Yajie Zhai, Wenhua Huang, Hua Jiang, Qingyu Lv, Decong Kong, Yongqiang Jiang

2020Infection and Immunity30 citationsDOIOpen Access PDF

Abstract

Streptococcus suis serotype 2 is a crucial pathogenic cause of bacterial meningitis, a life-threatening disease with neurological sequelae and high rates of mortality. Inflammation triggered by S. suis infection must be precisely regulated to prevent further tissue damage.

Topics & Concepts

Streptococcus suisMeningitisBiologyMicrobiologyInflammationSerotypeImmunologyDiseaseBacterial meningitisVirologyVirulenceMedicineGenePathologyBiochemistryPsychiatryS100 Proteins and AnnexinsStreptococcal Infections and TreatmentsInflammasome and immune disorders