ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer
Guanpeng Wang, Yeni Romero, Indhujah Thevarajan, Anna Żółkiewska
Abstract
and gene expression signature of TINs/PMN-MDSCs. Collectively, these results implicate ADAM12 in immunosuppression within the TME in TNBC.
Topics & Concepts
Triple-negative breast cancerImmune checkpointCancer researchTumor microenvironmentImmune systemMedicineImmunotherapyBreast cancerT cellCancerCancer cellImmunologyMetastasisInternal medicineImmune cells in cancerCancer Immunotherapy and BiomarkersCancer Cells and Metastasis