Small molecule-mediated co-assembly of amyloid-β oligomers reduces neurotoxicity through promoting non-fibrillar aggregation
Hao Liu, Chengyuan Qian, Tao Yang, Yanqing Wang, Jian Luo, Changli Zhang, Xiaohui Wang, Xiaohui Wang, Xiaoyong Wang, Xiaoyong Wang, Zijian Guo
Abstract
A rational design of pincer-like scaffold-based small molecule with blood-brain barrier permeability that can specifically co-assemble with low molecular weight Aβ oligomers to form non-fibrillar, degradable, non-toxic co-aggregates.
Topics & Concepts
NeurotoxicityChemistrySmall moleculeBiophysicsMoleculePermeability (electromagnetism)Rational designAmyloid (mycology)Amyloid βBiochemistryMembraneNanotechnologyMaterials scienceOrganic chemistryBiologyToxicityMedicineInorganic chemistryDiseasePathologyAlzheimer's disease research and treatmentsSupramolecular Self-Assembly in MaterialsNanocluster Synthesis and Applications