Curcumin-loaded PEGylated mesoporous silica nanoparticles for effective photodynamic therapy
Gaizhen Kuang, Qingfei Zhang, Shasha He, Ying Liu
Abstract
anti-cancer efficacy of MSN-PEG@Cur were evaluated in detail step by step. The results indicated that MSN-PEG@Cur could be effectively endocytosed into cells and release Cur, which can promptly generate ROS upon irradiation, achieving effective PDT in cancer treatment. This MSNs-based drug delivery system provides an alternative strategy for Cur loading and PDT of cancer.
Topics & Concepts
CurcuminMesoporous silicaPhotodynamic therapyBioavailabilityDrug deliveryChemistryNanoparticlePEG ratioPhotosensitizerNanotechnologyEndocytosisMaterials scienceMesoporous materialPharmacologyOrganic chemistryMedicineBiochemistryCatalysisCellFinanceEconomicsNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research Studies