Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice
Yuchuan Zhou, JoëlR Drevet, Chen Chu, Yu Lu, Joëlle Henry-Berger, Yanfei Ru, Ayhan Kocer, Alexandre Champroux, Zhi-Tong Li, Miao He, Shengsong Xie, Wubin Ma, Minjie Ni, Zimei Ni, Yunli Guo, Zhaoliang Fei, Lan‐Tao Gou, Qiang Liu, Samanta Sharma, Yu Zhou, Mo‐Fang Liu, C.–K. Chen, Andrew L. Eamens, Brett Nixon, Yonglian Zhang
Abstract
mice. Importantly, the oxidative stress response genes tend to have more targeting piRNAs, and many of them were among the top increased genes upon the loss of GPX5. Taken together, our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible involvement in the aging and oxidative stress-mediated responses.
Topics & Concepts
Oxidative stressBiologyGlutathione peroxidaseEpididymisTranscriptomeReactive oxygen speciesGeneCell biologySpermGeneticsGene expressionSuperoxide dismutaseEndocrinologySperm and Testicular FunctionSelenium in Biological SystemsChromosomal and Genetic Variations