Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis
Amit Subedi, Qiang Liu, Dhanoop Manikoth Ayyathan, David Sharon, Séverine Cathelin, Mohsen Hosseini, Changjiang Xu, Véronique Voisin, Gary D. Bader, Angelo D’Alessandro, Eric R. Lechman, John E. Dick, Mark D. Minden, Jean Wang, Steven M. Chan
Topics & Concepts
Nicotinamide phosphoribosyltransferaseBiologyStem cellMyeloid leukemiaHaematopoiesisCancer researchApoptosisProgenitor cellDownregulation and upregulationCell biologySterol regulatory element-binding proteinBiochemistryPharmacologyNAD+ kinaseEnzymeCholesterolSterolGeneUbiquitin and proteasome pathwaysSphingolipid Metabolism and SignalingHistone Deacetylase Inhibitors Research