A direct route to six and seven membered lactones <i>via</i> γ-C(sp<sup>3</sup>)–H activation: a simple protocol to build molecular complexity
Jayabrata Das, Pravas Dolui, Wajid Ali, Jyoti Prasad Biswas, Hediyala B. Chandrashekar, Gaurav Prakash, Debabrata Maiti
Abstract
)-H activation. The γ-C-H bond containing aliphatic carboxylic acids provide six or seven membered lactones depending on the olefin partner in the presence of a palladium catalyst. A mechanistic investigation suggests that C-H activation is the rate-determining step. Further transformations of the lactones have been carried out to showcase the applicability of the present strategy.
Topics & Concepts
Simple (philosophy)Protocol (science)Combinatorial chemistryChemistryStereochemistryPhilosophyMedicinePathologyAlternative medicineEpistemologyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsCatalytic Cross-Coupling Reactions