Time-restricted feeding combined with resistance exercise prevents obesity and improves lipid metabolism in the liver of mice fed a high-fat diet
Robson Damasceno de Lima, Renan Fudoli Lins Vieira, Vítor Rosetto Muñoz, Amandine Chaix, Ana Paula Azevêdo Macêdo, Gabriel Calheiros Antunes, Maíra Felonato, Renata Rosseto Braga, Susana Castelo Branco Ramos Nakandakari, Rafael Calais Gaspar, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Leandro Pereira de Moura, Rania A. Mekary, Eduardo R. Ropelle, José Rodrigo Pauli
Abstract
Whether time-restricted feeding (TRF) combined with resistance exercise training (RT) may be more efficient compared with these interventions alone is still unclear. We show that when combined with RT, TRF provided additional benefits, being more effective in increasing energy expenditure, preventing weight gain, and regulating glycemic homeostasis than each intervention alone. Thus, our results demonstrate that TRF and RT have complementary actions on some synergistic pathways that prevented obesity and hepatic liver accumulation.