Regulatory Roles of Circular RNAs in Coronary Artery Disease
Shuchen Zhang, Wenjing Wang, Xiaoguang Wu, Xiang Zhou
Abstract
Coronary artery disease (CAD) is a cardiac disorder caused by abnormal structure or function of the coronary artery, which leads to myocardial ischemia and hypoxia. CAD is a major cause of morbidity and mortality worldwide. Although there are currently effective drug therapies, there is a pressing need to find novel molecular therapeutic targets for CAD. The development of molecular biology technology has allowed the recognition of circular RNAs (circRNAs) as a novel class of noncoding RNAs that regulate gene function. The pathological roles of circRNAs in CAD have not, however, been comprehensively summarized. In this article, we review published research linking circRNAs to CAD and summarize the regulatory roles of circRNAs in the pathogenesis of coronary atherosclerosis, myocardial infarction, ischemia/reperfusion injury, and ischemic heart failure.