Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promote the progression of PDAC
Shengnan Lv, Jian Zhang, Xinyu Peng, Huan Liu, Tongjia Chu, Ziyu Liu, Kehang Duan, Jianxiong Guo, Jie Wang, Yan Liu, Feng Wei
Abstract
Hsa_circ_0058495 promotes PDAC progression by stabilizing IGF2BP2 and activating the MEKK1-ERK signaling cascade, while exosomal transfer of hsa_circ_0058495 drives M2 macrophage polarization to reinforce tumor-associated immunosuppression. These findings establish hsa_circ_0058495 as a pivotal regulator of PDAC progression and underscore its potential utility as both a diagnostic biomarker and a therapeutic target.
Topics & Concepts
Cancer researchDownregulation and upregulationUbiquitinCell biologyBiologyRegulatorTumor progressionMicrovesiclesPhosphorylationRNACell growthSignal transductionExosomeBiomarkerChemistryCarcinogenesisMdm2HDAC6Macrophage polarizationCell cycleBiogenesisSmall interfering RNAGene knockdownStress granuleImmunoprecipitationMacrophageClathrinTumor microenvironmentRegulation of gene expressionRNA modifications and cancerinterferon and immune responsesCircular RNAs in diseases