Sappanone a alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis via activating the SIRT1/Nrf2 signaling pathway
Zhi Zhang, Nan-Zhi Zhang, Meng Li, Xing Ma, Yusheng Qiu
Topics & Concepts
ChondrocyteInflammationChemistryCell biologyOsteoarthritisGPX4CartilageMMP3Extracellular matrixCancer researchSignal transductionApoptosisOxidative stressPharmacologyImmunologyIn vitroMedicineGene expressionBiochemistryBiologyPathologySuperoxide dismutaseAnatomyGlutathione peroxidaseGeneAlternative medicineCancer-related molecular mechanisms researchCircular RNAs in diseasesOsteoarthritis Treatment and Mechanisms