Anti-inflammatory effect of IGF-1 is mediated by IGF-1R cross talk with GPER in MPTP/MPP+-induced astrocyte activation
Liang-Jie Yuan, Mei Zhang, Su Chen, Wenfang Chen
Topics & Concepts
GPERNeuroprotectionMAPK/ERK pathwayMPTPNitric oxide synthasep38 mitogen-activated protein kinasesDownregulation and upregulationAstrocyteChemistryKinasePharmacologyEstrogen receptorBiologyEndocrinologyNitric oxideInternal medicineCell biologyBiochemistryMedicineDopamineDopaminergicCentral nervous systemBreast cancerCancerGeneEstrogen and related hormone effectsCytokine Signaling Pathways and InteractionsGrowth Hormone and Insulin-like Growth Factors