A membrane targeted multifunctional cationic nanoparticle conjugated fusogenic nanoemulsion (CFusoN): induced membrane depolarization and lipid solubilization to accelerate the killing of<i>Staphylococcus aureus</i>
Somashree Bose, Yogita Dahat, Deepak Kumar, Saikat Haldar, Sujoy K. Das
Abstract
hemolytic activity or cytotoxicity against red blood cells (RBCs) and L929 fibroblast cells, respectively, at its bactericidal concentration. Furthermore, a porcine skin wound infection model exhibited the enhanced wound cleansing potency of CFusoN in comparison to the commercially available wound cleansers. The obtained antibacterial activity, biocompatibility and skin wound disinfection efficacy of the NECNP demonstrated the formulation of a cell targeted CFusoN as a promising translatable strategy to combat bacterial infection.
Topics & Concepts
Conjugated systemStaphylococcus aureusMembraneNanoparticleCationic polymerizationBiophysicsSolubilizationLipid bilayerDepolarizationMaterials scienceChemistryNanotechnologyBiochemistryBacteriaPolymerBiologyOrganic chemistryPolymer chemistryGeneticsAntimicrobial Peptides and ActivitiesBacterial biofilms and quorum sensingStreptococcal Infections and Treatments