Synthesis and characterization of Cu(II)-pyrazole complexes for possible anticancer agents; conformational studies as well as compatible in-silico and in-vitro assays
Enas Aljuhani, Meshari M. Aljohani, Amerah Alsoliemy, Reem Shah, Hana M. Abumelha, Fawaz A. Saad, Aisha Hossan, Zehbah A. Al‐Ahmed, Ahmed Alharbi, Nashwa M. El‐Metwaly
Abstract
values were calculated and represent Cu(II) complexes as outstanding cytotoxic agents which revealed superiority on the reference drug itself.
Topics & Concepts
PyrazoleIn silicoDocking (animal)ChemistryIn vitroLigand (biochemistry)Molar conductivityMCF-7Combinatorial chemistryStereochemistryCrystallographyCancer cellCancerBiochemistryReceptorOrganic chemistryMetalBiologyHuman breastNursingMedicineGeneticsGeneMetal complexes synthesis and propertiesSynthesis and biological activityComputational Drug Discovery Methods