GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
David Aguilar-Recarte, Emma Barroso, Anna Gumà, Javier Pizarro‐Delgado, Lucía Peña, Maria Ruart, Xavier Palomer, Walter Wahli, Manuel Vázquez‐Carrera
Abstract
mice show reduced AMPK activation in skeletal muscle, whereas GDF15 administration results in AMPK activation in this organ. Collectively, these data reveal a mechanism by which PPARβ/δ activation increases GDF15 levels via AMPK and p53, which in turn mediates the metabolic effects of PPARβ/δ by sustaining AMPK activation.
Topics & Concepts
AMPKPeroxisome proliferator-activated receptorChemistryCell biologyInternal medicineEndocrinologyReceptorBiologyBiochemistryProtein kinase AMedicinePhosphorylationGDF15 and Related BiomarkersNutrition and Health in AgingNuclear Receptors and Signaling