Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticles<i>in vivo</i>
Qingguo Zhong, Chunxiong Zheng, Ke Yi, Rachel L. Mintz, Shixian Lv, Yu Tao, Mingqiang Li
Abstract
to enhance the therapeutic effects. Herein, we briefly review the development of lipid-based nanoparticles, from simple self-assembled nanovesicle-structured liposomes to multifunctional lipid nanoparticles. Subsequently, we summarize the strategies that regulate their tissue distribution, cell internalization, and drug release, highlighting the importance of the structural and componential design. We conclude with insights for further research to advance lipid-based nanotechnology.
Topics & Concepts
InternalizationIn vivoNanoparticleChemistryComputer scienceCellNanotechnologyCell biologyBiologyBiochemistryMaterials scienceBiotechnologyRNA Interference and Gene DeliveryLipid Membrane Structure and BehaviorNanoparticle-Based Drug Delivery