Rivaroxaban eutectics with improved solubility, dissolution rates, bioavailability and stability
Parth S. Shaligram, Christy P. George, Himanshu Sharma, Kakasaheb Mahadik, Sharvil Patil, Kumar Vanka, S. Arulmozhi, Rajesh G. Gonnade
Abstract
Six acidic coformers were used to prepare eutectics of rivaroxaban (RXB), a factor Xa inhibitor. The eutectics displayed improved solubility, dissolution rate, and bioavailability of RXB, without compromising on its stability.
Topics & Concepts
RivaroxabanBioavailabilitySolubilityDissolutionEutectic systemChemistryChromatographyChemical engineeringPharmacologyOrganic chemistryMedicineInternal medicineAlloyAtrial fibrillationWarfarinEngineeringAtrial Fibrillation Management and OutcomesLubricants and Their AdditivesOrganometallic Compounds Synthesis and Characterization