Multifunctional Micro/Nanofiber Based‐Dressing Patch with Healing, Protection, and Monitoring Capabilities for Advanced Wound Care
Ji‐Hwan Ha, Jae Yun Kim, Dahong Kim, Junseong Ahn, Yongrok Jeong, Jiwoo Ko, Soonhyoung Hwang, Sohee Jeon, Young Hun Jung, Jimin Gu, Hyeonseok Han, Jungrak Choi, Gihun Lee, Moonjeong Bok, Su A Park, Yee Sook Cho, Jun‐Ho Jeong, Inkyu Park
Abstract
Abstract Considerable efforts have been devoted to developing wound dressings with various functions, including rapid cell proliferation, protection against infection, and wound state monitoring to minimize severe pain and the risks of wound‐caused secondary infections. However, it remains challenging to diagnose wound conditions and achieve integration of the above functions without specialized equipment and expertise in wound care. This study describes an electrospun composite micro/nanofiber‐based bilayer‐dressing patch comprising a healing‐support layer (hyaluronic acid, gelatin, and dexpanthenol) and a protective/monitoring layer (curcumin and polycaprolactone). The improved cell regeneration function and biocompatibility of the healing‐support layer enable rapid healing, as evidenced by the expedited growth of fibroblasts. The superior antimicrobial properties (against Escherichia coli and Staphylococcus aureus ) and visible color changes within the pH range of wound lesions (pH 6–9) of the protective/monitoring layer make the dressing suitable for advanced wound care. The wounds inflicted on BALB/c mice heal rapidly (12 days) without scars while the wound state can be diagnosed by the change in color of the dressing patch. The multifunctional wound dressing patch developed in this study is expected to promote wound healing and monitor wound state; thus, facilitating convenient wound management.