Pathogenesis of inclusion body myositis
Steven A. Greenberg
Abstract
PURPOSE OF REVIEW: To review the pathogenesis of inclusion body myositis (IBM). RECENT FINDINGS: IBM is an autoimmune disease. Multiple arms of the immune system are activated, but a direct attack on muscle fibers by highly differentiated T cells drives muscle destruction. SUMMARY: Further understanding of the pathogenesis of IBM guides rational approaches to developing therapeutic strategies.
Topics & Concepts
PathogenesisInclusion body myositisMyositisIBMMedicineImmunologyDiseasePathologyMaterials scienceNanotechnologyInflammatory Myopathies and DermatomyositisMuscle and Compartmental DisordersSkin Diseases and Diabetes