A Co(<scp>ii</scp>)-catalyzed asymmetric ring opening reaction of spiro-epoxyoxindoles with allylboron
Liang Wu, Qihang Shao, Li Kong, Jianzhong Chen, Quhao Wei, Wanbin Zhang
Abstract
A Co(<sc>ii</sc>)/BOX-catalyzed asymmetric allylation of spiroepoxyoxindoles was developed, which is the first stereoconvergent allylation of epoxides, yielding chiral oxindoles bearing quaternary stereocenters.
Topics & Concepts
StereocenterChemistryCatalysisRing (chemistry)Enantioselective synthesisMedicinal chemistryStereochemistryCombinatorial chemistryOrganic chemistryAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry MethodsCatalytic C–H Functionalization Methods