Chronic metformin treatment decreases cardiac injury during ischemia-reperfusion by attenuating endoplasmic reticulum stress with improved mitochondrial function
Qun Chen, Jeremy Thompson, Ying Hu, Edward J. Lesnefsky
Abstract
isolated heart perfusion with 25 min. global ischemia and 60 min. reperfusion. Infarct size was measured. The contents of CHOP and cleaved ATF6 were decreased in metformin-treated 24 mo. mice compared to vehicle, supporting a decrease in ER stress. Metformin treatment improved OXPHOS in IFM in 24 mo. using a complex I substrate. Metformin treatment decreased infarct size following ischemia-reperfusion. Thus, metformin feeding decreased cardiac injury in aged mice during ischemia-reperfusion by improving pre-ischemic mitochondrial function via inhibition of ER stress.
Topics & Concepts
MetforminCardioprotectionMedicineIschemiaReperfusion injuryMitochondrionCardiac function curvePharmacologyOxidative stressInternal medicineEndocrinologyEndoplasmic reticulumAnesthesiaChemistryDiabetes mellitusHeart failureBiochemistryMitochondrial Function and PathologyCardiac Ischemia and ReperfusionAutophagy in Disease and Therapy