m6A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress
Lingfang Wang, Guankai Zhan, Yasen Maimaitiyiming, Yingfeng Su, Shitong Lin, Jinfeng Liu, Kunhui Su, Jiebo Lin, Shizhen Shen, Wentao He, Fenfen Wang, Jiafeng Chen, Siqi Sun, Yite Xue, Jiaxin Gu, Xiaojing Chen, Jian Zhang, Lu Zhang, Qianqian Wang, Kao-Jung Chang, Shih‐Hwa Chiou, Mikael Björklund, Hua Naranmandura, Xiaodong Cheng, Chih-Hung Hsu
Abstract
A RNA and its reader but also provide a heat-treatment-based therapeutic strategy for HPV-associated malignancies by specifically downregulating E7 mRNA-IGF2BP1 oncogenic complex.
Topics & Concepts
Messenger RNARNAHeat shock proteinCarcinogenesisHsp90Molecular biologyCell biologyRNA-binding proteinBiologyChemistryGeneticsGeneRNA modifications and cancerRNA Research and SplicingHVDC Systems and Fault Protection