Comprehensive Immunoprofiling of Pediatric Zika Reveals Key Role for Monocytes in the Acute Phase and No Effect of Prior Dengue Virus Infection
Daniela Michlmayr, Eun‐Young Kim, Adeeb Rahman, Rohit Raghunathan, Seunghee Kim‐Schulze, Yan Che, Selim Kalaycı, Zeynep H. Gümüş, Guillermina Kuan, Ángel Balmaseda, Andrew Kasarskis, Steven M. Wolinsky, Mayte Suárez‐Fariñas, Eva Harris
Abstract
monocytes as a potential biomarker of acute ZIKV infection. Strikingly distinct transcriptomic and immunophenotypic signatures are observed at all three time points. Interestingly, pre-existing dengue immunity has minimal impact on the innate immune response to Zika. Finally, this comprehensive immune profiling and network analysis of ZIKV infection in children serves as a valuable resource.
Topics & Concepts
Zika virusDengue virusDengue feverVirologyInnate immune systemBiologyImmunologyCD14ChemokineFlavivirusImmune systemImmunophenotypingVirusCytokine stormMedicineInfectious disease (medical specialty)DiseaseFlow cytometryCoronavirus disease 2019 (COVID-19)PathologyMosquito-borne diseases and controlViral Infections and VectorsMalaria Research and Control