Palladium-catalysed stereoselective [3 + 2] annulation of vinylethylene carbonates and tryptanthrin-based ketones
Yang Fan, Qing‐Zhu Li, Jun‐Long Li, Bin Zhang, Zhen Dai, Ke Xie, Rong Zeng, Liang Zou, Xiang Zhang
Abstract
The first example of palladium-catalysed [3 + 2] annulation of VECs and ketones has been developed, allowing the efficient synthesis of indoloquinazolinones in generally excellent yields with good stereoselectivity.
Topics & Concepts
AnnulationStereoselectivityChemistryPalladiumOrganic chemistryCatalysisCombinatorial chemistryMedicinal chemistryQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsSynthesis and Biological Evaluation