Copper-mediated [3 + 2] cycloaddition of trifluoroacetimidoyl chlorides and <i>N</i>-isocyanoiminotriphenylphosphorane for the synthesis of 3-trifluoromethyl-1,2,4-triazoles
Hefei Yang, Shu‐Ning Lu, Yu‐Fei Song, Zhengkai Chen, Xiao‐Feng Wu
Abstract
Herein, a facile and straightforward route to synthesize 3-trifluoromethyl-1,2,4-triazoles via copper-mediated [3 + 2] cycloaddition of trifluoroacetimidoyl chlorides and N -isocyanoiminotriphenylphosphorane (NIITP) has been described.
Topics & Concepts
ChemistryCycloadditionTrifluoromethylCopperMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisAlkylFluorine in Organic ChemistryClick Chemistry and ApplicationsCyclopropane Reaction Mechanisms