Recent Advances of Curcumin Derivatives in Breast Cancer
Ying Yin, Yan Tan, Xueni Wei, Xiaoshun Li, Hongfei Chen, Zehua Yang, Guotao Tang, Yao Xu, Pengbing Mi, Xing Zheng
Abstract
Curcumin is a potential plant-derived drug for the treatment of breast cancer. Poor solubility and bioavailability are the main factors that limit its clinical application. Various structural modification strategies have been developed to improve the anti-breast cancer activity of curcumin. This review focuses on the difference of modification sites and heterocyclic/non-heterocyclic modifications to systematically summarize curcumin derivatives with better anti-breast cancer activity.
Topics & Concepts
CurcuminBreast cancerChemistryBioavailabilityPharmacologyCombinatorial chemistryDrugCancerInternal medicineBiochemistryMedicineCurcumin's Biomedical ApplicationsNatural product bioactivities and synthesisBioactive Compounds and Antitumor Agents