Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds with a Multifunctional Wound Dressing
Rahimeh B. Atashgah, Amir Reza Ghasemi, Mohammad Raoufi, Mohammad‐Amin Abdollahifar, Steven Zanganeh, Hossein Nejadnik, Alieh Abdollahi, Shahriar Sharifi, Baltazar Lea, Miguel Cuerva, Mehdi Akbarzadeh, Carmen Alvarez‐Lorenzo, Seyed Nasser Ostad, Andrea S. Theus, Doris L. LaRock, Christopher N. LaRock, Vahid Serpooshan, Rouzbeh Sarrafi, Ki‐Bum Lee, Hojatollah Vali, Holger Schönherr, Lisa J. Gould, Pablo Taboada, Morteza Mahmoudi
Abstract
Current treatment of chronic wounds has been critically limited by various factors, including bacterial infection, biofilm formation, impaired angiogenesis, and prolonged inflammation. Addressing these challenges, we developed a multifunctional wound dressing-based three-pronged approach for accelerating wound healing. The multifunctional wound dressing, composed of nanofibers, functional nanoparticles, natural biopolymers, and selected protein and peptide, can target multiple endogenous repair mechanisms and represents a promising alternative to current wound healing products.