CRISPR-Cas knockout of miR21 reduces glioma growth
Lisa Nieland, Thomas S. van Solinge, Pike-See Cheah, Liza Morsett, Joseph El Khoury, Joseph I. Rissman, Benjamin P. Kleinstiver, Marike L. D. Broekman, Xandra O. Breakefield, Erik R. Abels
Abstract
. Overall, we identified miR-21 as a potential target for CRISPR-based therapeutics in glioma.
Topics & Concepts
microRNAGliomaCRISPRBiologyDownregulation and upregulationGeneCancer researchRegulation of gene expressionCell growthComputational biologyLong non-coding RNACell biologyGeneticsMicroRNA in disease regulationCRISPR and Genetic EngineeringRNA regulation and disease