Inhibition of cardiomyocyte apoptosis post-acute myocardial infarction through the efficient delivery of microRNA-24 by silica nanoparticles
Hong Yu, Yi Li, Ruirui Zhang, Mengchen Shen, Yuting Zhu, Zhang Qiang, Huiliang Liu, Dong Han, Xiaoli Shi, Jiao Zhang
Abstract
experiments revealed that over-expressed miR-24 additionally significantly improves ventricular remodeling and cardiac function in Sprague-Dawley (SD) rats after coronary artery ligation. In summary, our novel delivery system serves as a therapeutic miRNA formulation for cardiovascular disease treatment.
Topics & Concepts
ApoptosisMyocardial infarctionmicroRNANanoparticleCardiologyChemistryInternal medicineMedicineCell biologyNanotechnologyMaterials scienceBiologyBiochemistryGeneMicroRNA in disease regulationRNA Interference and Gene DeliveryElectrospun Nanofibers in Biomedical Applications